REDONDO BEACH, CA--(Marketwired - Jul 27, 2017) - SECFilings.com, a leading financial news and information portal offering
free real-time public company filing alerts, announces the publication of an article discussing PreveCeutical Medical Inc. (CNSX: PREV) and its ground breaking research targeting a gene
therapy for Type 2 diabetes and obesity through silencing of the protein, PTP-1B.
Diabetes is a leading cause of death in the developed world, killing one person every six seconds around the world. In
addition to $827 billion in costs last year, analysts expect global gross domestic product losses to exceed $1.7 trillion between
2011 and 2030, according to the World Health Organization. There is no curative therapy for diabetes at the moment, but new
techniques like gene suppression could dramatically change the game over the coming years.
Targeting PTP-1B Proteins
Type 2 diabetes (T2D) is characterized by insulin resistance, which is a pathological condition that occurs when cells fail to
respond normally to the blood sugar lowering hormone, insulin. Normally, the body produces insulin when glucose enters the
bloodstream from carbohydrate consumption and its levels are elevated beyond safe, homeostatic levels, triggering cells/tissues
to 'absorb' the glucose, so bringing it back down to normal levels. Insulin resistance means that these cells never receive this
important trigger so blood sugar levels remain elevated beyond safe levels.
The protein tyrosine phosphatase 1B -- or PTP-1B -- is a target that specifically addresses insulin resistance. By silencing
the gene encoding for the protein, patients could see improved insulin sensitization and weight loss as excessive PTP-1B levels
have also been implicated in adversely affecting the processing of fat, which is an important component of T2D pathology.
Unfortunately, efforts by drug companies to develop small molecule drugs to inhibit PTP-1B have been wholly unsuccessful due to
their unfavorable pharmacokinetic properties and off-target (adverse) effects.
The good news is that RNA-based therapies that inhibit production of PTP-1B may provide an alternative mechanism for
therapeutic intervention. In fact, researchers have already tailor-made siRNA therapeutics that target the gene, although the
biggest remaining challenge is finding ways to safely and efficiently deliver siRNAs into target cells. siRNA are rapidly
degraded in the circulation, much more so than small molecules, and so they need carriers that package, deliver and release their
payload, which in this case includes the liver, skeletal muscle and adipose (fat) tissue.
Developing a Program
PreveCeutical Medical is commencing ground breaking research targeting a gene therapy for T2D and obesity using PTP-1B. By
taking a gene-silencing approach, the company aims to selectively target the gene encoding for the protein PTP-1B only, which
sidesteps many of the safety and efficacy concerns associated with small molecule drugs. Reducing PTP-1B levels is expected to
reinstate signalling pathways that promote glucose uptake by our cells/tissues, while also facilitating improved processing of
fat.
The company will first engineer a panel of novel, tissue-targeted bio-responsive gene carrier and release systems to address
the biggest issue -- delivering and releasing the payload to intended targets. In parallel the company will synthesize a library
of chemically-modified siRNA's targeting PTP-1B and conduct toxicity and efficacy studies in cell and animal models of diabetes
and obesity, paving the way for further pre-clinical evaluation in the coming years.
Dr. Harendra (Harry) Parekh, Ph.D at the University of Queensland's Pharmacy Australia Centre of Excellence is directing the
research program. Dr. Parekh heads the Drug/Gene Delivery Group with his team developing highly innovative and translational
medicine delivery systems in conjunction with physicians whose expertise span cancer, diabetes, macular disease, infectious
disease, and traditional medicine.
Diverse Product Pipeline
PreveCeutical Medical is also involved in several other businesses aside from its gene therapy efforts, which investors may
want to consider.
The company's CellB9® is a homeopathic medicine that contains blue scorpion venom, which may be beneficial in regulating and
preventing cancer progression. The venom is extremely rich in a variety of proteins that abnormal cells consume and research has
shown promise across a wide range of potential medical indications.
In the cannabis industry, the company is developing the first cannabidiol (CBD) nose-to-brain delivery system via its
Sol-Gels, which may provide relief across a range of indications, including pain, inflammation, seizures, and mental illnesses.
These Sol-Gels have the potential to deliver improved bioavailability relative to many other cannabinoid delivery systems, while
enabling an extended release feature that enables once or twice weekly administration.
Please follow the link to read the full article and see the interview: http://analysis.secfilings.com/articles/188-diabetes-silence-the-messenger-don-t-shoot-it
For more information, visit the company's website.
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