BERKELEY, CA and VANCOUVER, BC --(Marketwired - July 31, 2017) - BriaCell
Therapeutics Corp. ("BriaCell" or the "Company") (TSX VENTURE:
BCT) (OTCQB: BCTXF), an immuno-oncology focused biotechnology company with a proprietary
vaccine technology, is pleased to announce the opening of a new clinical site, Florida Cancer Care in Plantation, FL and the
appointment of Dr. Elizabeth Tan-Chiu, a board certified breast medical oncologist and Founder and Research Director of Florida
Cancer Care in Plantation, FL, as the clinical site's principal investigator. Dr. Tan-Chiu will work closely with Cancer Insight,
LLC., BriaCell's contract research organization, to manage the clinical and regulatory aspects of the clinical trial on behalf of
BriaCell.
Dr. Elizabeth Tan-Chiu is a highly respected research scientist and oncologist with experience in all medical aspects of
breast and ovarian cancer treatment including anti-hormonal therapy, chemotherapy and "targeted therapy". Through her work with
the National Surgical Adjuvant Breast and Bowel Project (NSABP), Dr. Tan-Chiu excelled her research ambitions under the
mentorship of Dr. Bernard Fisher, a pioneer in the biology and treatment of breast cancer. She has authored and co-authored
numerous publications, and participated in clinical trials of virtually every aspect of breast cancer treatment including
pioneering work in the use of Trastuzumab (Herceptin), Bevacizimab (Avastin) and Lapatanib (Tykerb) therapies.
"We are impressed with Dr. Tan-Chiu's credentials and her profound knowledge and experiences in the management of breast
cancer clinical trials, and we are grateful to have her as a principal investigator for the Phase I/IIa clinical trial of
BriaVax™, our lead vaccine candidate for management of advanced breast cancer," stated Dr. William Williams, President & CEO of
BriaCell. "We are committed to excellence in patient care, and we are delighted to have Florida Cancer Care, which is known for
outstanding cancer care, as our second site for the clinical trials of BriaVax™. We expect that the addition of Florida Cancer
Care will provide availability to the vaccine for patients in the eastern regions of the US and speed up the process of patient
enrollment in our ongoing clinical trial with BriaVax™."
"We are excited to join the team to evaluate the safety and activity of BriaVax™ in patients with advanced breast cancer with
the goal of making treatments available to patients with few treatment options," commented Dr. Tan-Chiu. "We are very impressed
with preliminary safety and efficacy data of BriaVax™ in advanced breast cancer patients, and look forward to working with the
BriaCell team to advance the clinical development of its lead drug candidate."
BriaVax™ is a whole-cell breast cancer vaccine genetically engineered to release granulocyte macrophage colony-stimulating
factor (GM-CSF), a substance that activates the immune system. Previously, a small Phase I study documented very prompt and near
complete regression of metastatic breast cancer deposits in the breast, lung, soft tissue, and even the brain. The ongoing
open-label Phase I/IIa study will evaluate BriaVax™ in up to 24 advanced breast cancer patients. This trial is listed in
ClinTrials.gov as NCT03066947. The trial is being conducted along with the co-development of BriaDx™, our companion diagnostic
test. The interim data for the first 10 patients is expected by the first quarter of 2018.
About BriaCell
BriaCell is an immuno-oncology focused biotechnology company developing a targeted and safe approach to the management of
cancer. BriaCell's mission is to serve late-stage cancer patients with no available treatment options.
Immunotherapy has come to the forefront of the fight against cancer, harnessing the body's own immune system in recognizing
and selectively destroying the cancer cells while sparing normal ones. Immunotherapy, in addition to generally being more
targeted and less toxic than commonly used types of chemotherapy, is also thought to be a strong type of approach aimed at
preventing cancer recurrence.
BriaVax™, the Company's lead product candidate, is a genetically engineered whole-cell vaccine derived from a human breast
tumor cell line. It is believed to activate the immune system to recognize and eliminate cancerous cells by inducing
tumor-directed T cell and potentially antibody responses. The Company has already demonstrated encouraging clinical results, and
is intent on building upon these results to further advance BriaVax™ through additional FDA-approved clinical trials in order to
help cancer patients with limited therapeutic options. The results of two previous Phase I clinical trials (one with the
precursor cell line not genetically engineered to produce GM-CSF and one with BriaVax™) have been encouraging in patients with
advanced breast cancer. Most notably, one patient with metastatic breast cancer responded to BriaVax™ with substantial reduction
in tumor burden including lung and brain metastases. The company is currently conducting a Phase I/IIa clinical trial for
BriaVax™ in patients with advanced breast cancer whose disease has progressed following at least one prior treatment course.
For additional information on BriaCell, please visit our website: http://briacell.com
About the Phase I/IIa Clinical Trial
The Phase I/IIa clinical trial is an open-label study enrolling up to 24 late-stage breast cancer patients with recurrent
and/or metastatic disease. Patients will be administered BriaVax™ every two weeks for the first month of treatment, then monthly
up to one year.
The primary objective of the clinical trial is to evaluate the safety of BriaVax™ in study subjects, and the principal
secondary objective is an evaluation of the tumor size reduction. Tumor response will be monitored every three months during the
study. The trial will also evaluate progression-free survival (PFS) and overall survival (OS).
For additional details regarding the clinical trial, please visit:
https://www.clinicaltrials.gov/ct2/show/NCT03066947
About Florida Cancer Care
Based in Broward and Palm Beach, Florida Cancer Care (FCRI) provides both domestic and international patients with the most
innovative cancer care with the highest level of service. The physicians, dedicated to excellence, have been recipients of
numerous honors and awards with a longstanding track record to provide the best quality service -- consistently throughout the
years -- to their patients.
FCRI is deeply committed to finding new and improved ways to prevent, diagnose and treat cancer. It offers FDA approved
clinical research trials to provide the patients alternatives other than generic therapies usually offered by other general
oncologists. The patients and physicians are encouraged to help conquer cancer by joining FCRI network and play an integral part
in the development of new and better therapies.
For additional information on Florida Cancer Care, please visit: http://www.floridacancercare.com
Cautionary Note Regarding Forward-Looking Information
Except for the statements of historical fact, this news release contains "forward-looking information" within the meaning of
the applicable Canadian securities legislation which involves known and unknown risks relevant to the Company in particular to
the biotechnology and pharmaceutical industries in general, uncertainties and other factors that may cause actual events to
differ materially from current expectation. These risks are more fully described in the Company's public filings available at
www.sedar.com. Other forward-looking information in this news release includes
but is not limited to the intended use of proceeds of the offering and other terms of the offering, the expected timing of
completion of the offering, the Company's ability to satisfy the conditions to completion of the offering and the need for
additional financing.
Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this
press release. The Company disclaims any intention or obligation, except to the extent required by law, to update or revise any
forward-looking statements, whether as a result of new information, future events or otherwise.
Attachment Available:
http://www.marketwire.com/library/MwGo/2017/7/31/11G143411/BriaCell_Appoints_Top_Oncologist_and_Opens_Second_-f1ddb0d757f4a9d6b8f46acec743a783.pdf