ANN ARBOR, Mich., June 19, 2018 (GLOBE NEWSWIRE) -- Zomedica Pharmaceuticals Corp. (NYSE American:ZOM) (TSX-V:ZOM) (“Zomedica” or the “Company”), a
veterinary diagnostic and pharmaceutical company, today provided a product development update.
Diagnostic Update
ZM-017: Circulating tumor cell assay platform for dogs
As previously disclosed, Zomedica has partnered with Celsee, Inc. (“Celsee”) to develop Celsee’s circulating tumor cell, or CTC,
assay, also known as a “liquid biopsy” for use by veterinarians as a cancer diagnostic. The liquid biopsy is a blood test that we
believe has the potential to detect the presence of CTCs, which are cells that have shed from a primary tumor into neighboring
blood vessels and are transported throughout the body’s circulatory system. We are focusing our development work on testing for
difficult to biopsy cancers such as hemangiosarcoma and osteosarcoma in canines. If our development work is successful, we believe
this liquid biopsy test will enable veterinarians to detect these hard-to-diagnose cancers with a simple blood draw. In line with
the Company’s previously disclosed estimates, clinical validation of ZM-017 began during the first half of 2018. Assuming the
successful conclusion of the clinical validation, we continue to expect to commence the marketing of ZM-017 during the second half
of 2018.
ZM-020: Point-of-care pathogen detection platform for fecal and urine specimens
As previously announced, Zomedica has partnered with Seraph Biosciences, Inc. (“Seraph”) to develop Seraph’s in-clinic
diagnostic analyzer for use in the detection of pathogens in companion animals. Our development work is focusing on the use of
Seraph’s technology for comprehensive fecal and urine analysis. Detection of fecal parasites, urine bacteria (“urinary tract
infection” or “UTI”) and crystals is time-consuming, error-prone and often requires additional outside testing for comprehensive
evaluation. If our development work is successful, we believe our analyzer will be able to perform these analyses in seconds,
without the need for centrifugation or the use of reagents. The Company is also developing the ability to detect leptospirosis in
the urine of infected animals. Leptospirosis is a potentially life-threatening zoonotic disease. Current diagnostic solutions are
limited by interference with vaccination and can take days for a confirmatory diagnosis. If our development work is successful, we
believe our analyzer will be able to overcome these limitations.
The company expects to begin marketing of ZM-020 in the second half of 2018.
In the longer term, Zomedica also intends to develop additional applications for this technology, including further development
of the pathogen detection library for urine and fecal analysis, as well as for respiratory and dermatological analysis. Targeted
pathogens may include bacteria, antibiotic resistant bacteria, viruses and fungi.
Therapeutic Update
ZM-007 and ZM-012: Metronidazole for acute diarrhea in dogs
ZM-012 is the Company’s tablet formulation of metronidazole targeting the treatment of acute diarrhea in dogs, currently only
available as a human generic. ZM-007 is a complementary oral suspension of metronidazole targeting the treatment of acute diarrhea
in small dog breeds and puppies under nine pounds or four kilograms, currently only available via compounding pharmacies.
The Company previously designated ZM-012 as its lead therapeutic drug candidate and ZM-007 as a follow-on candidate as a
bioequivalent. As previously disclosed, the Company expected to commence a pivotal safety study of ZM-012 in the first half of
2018, which it expected to complete in the second half of 2018. The Company held a pre-submission meeting for metronidazole with
the U.S. Food and Drug Administration Center for Veterinary Medicine (“FDA-CVM”) on December 13, 2017. Based on the feedback
received from the FDA-CVM at that meeting and in light of additional market research demonstrating approved alternatives to
compounded drugs, the Company has decided to prioritize its development of ZM-007 over ZM-012. The Company expects to commence a
pivotal safety study of ZM-007 in the first half of 2019. The Company expects to pursue approval pf ZM-012 as a bioequivalent to
ZM-007 assuming ZM-007 is approved by FDA-CVM.
ZM-006: Transdermal formulation of methimazole
ZM-006 is a transdermal gel formulation of methimazole targeting hyperthyroidism in cats. The Company previously disclosed that
it expected pilot testing of ZM-006 to be completed in the first half of 2018 and, assuming that such pilot testing was successful,
to commence and complete a pivotal safety study of ZM-006 in the second half of 2018. In an effort to improve dosing requirements,
the Company has decided to continue its pilot testing of ZM-006, which it now expects to complete in the second half of 2018.
Assuming that such pilot testing is successful, the Company also intends to commence a pivotal safety study of ZM-006 in the second
half of 2018.
ZM-011: Transdermal fluoxetine for feline behavioral disorders
ZM-011 is a transdermal formulation of fluoxetine, most commonly known as Prozac®, which is intended to treat behavioral
disorders in cats (e.g., inappropriate urination). Consistent with the Company’s earlier guidance, the Company expects to complete
pilot testing of ZM-011 in the second half of 2018.
About Zomedica
Based in Ann Arbor, Michigan, Zomedica (NYSE American:ZOM) (TSX-V:ZOM) is a veterinary diagnostic and pharmaceutical company
creating products for companion animals (canine, feline and equine) by focusing on the unmet needs of clinical veterinarians.
Zomedica’s product portfolio will include novel diagnostics and innovative therapeutics that emphasize patient health and practice
health. With a team that includes clinical veterinary professionals, it is Zomedica’s mission to give veterinarians the opportunity
to lower costs, increase productivity, and grow revenue while better serving the animals in their care. For more information, visit
www.ZOMEDICA.com.
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Investor Relations Contacts
Shameze Rampertab, CPA, CA
srampertab@zomedica.com
+1 647.283.3630
PCG Advisory Group
Kirin Smith, COO
ksmith@pcgadvisory.com
+1 646.863.6519
www.pcgadvisory.com
Media Contact
Andrea Eberle
aeberle@zomedica.com
+1 734.369.2555