Company Expands its Pterostilbene Based Portfolio into Brain Cancers
OCEANSIDE, Calif., July 16, 2018 (GLOBE NEWSWIRE) -- via OTC PR WIRE -- Therapeutics Solutions
International, Inc., (OTC Markets:TSOI) announced today the release of NeuroStilbene, a proprietary nano-formulation of
pterostilbene formulated for intranasal delivery.
Intranasal delivery is used with the intention to deliver high concentrations of substances into the brain across
what is called the "blood-brain barrier." This structure is a "security system" that keeps blood cells separate from the fluid
surrounding the brain. This barrier does provide oxygen and nutrients to be transported by the blood cells but prevents harmful
substances like bacteria or poisons from getting to the brain. While compounds such as pterostilbene [1,2], and alpha lipoic acid
[3], can bypass the BBB, it is anticipated that higher concentrations can be delivered through the intranasal route.
"Our pharmacokinetic trial data showed a 55% increase in serum concentration of nanoparticle pterostilbene over a
powdered and capsule form. We are therefore pleased to release a formulation of this product with double the potency and half-life
over traditional powder formulation for intranasal use," said Timothy Dixon, President, and CEO. "Late last year we filed a patent
on the synergistic inhibition of glioma using pterostilbene. Our data suggest that when pterostilbene is combined with brain cancer
therapeutics such as Temozolomide, Sertraline, or Gefitinib, their prognosis is improved. Furthermore, we observed that
pterostilbene causes an increase of immunogenicity in chemotherapy-treated cancer cells, providing heightened immunity to cancer
cells that escaped chemotherapy, theoretically enhancing patient prognosis," added Mr. Dixon.
"The pterostilbene molecule has numerous potential applications in neurology and neuro-oncology. The generation of
an intranasal formulation of pterostilbene opens the door for evaluating this molecule in a rapid manner in glioma and other brain
cancer patients, where safe therapeutics with favorable safety profiles are urgently needed," said Dr. Santosh Kesari, MD, Ph.D.,
and member of the Company's Scientific Advisory Board.
"We are working on integrating NeuroStilbene into various protocols that are currently in development in order to
enhance therapeutic options to patients with dreaded conditions such as brain tumors and neurodegenerative diseases," stated Dr.
James Veltmeyer, Chief Medical Officer of the Company.
About Therapeutic Solutions International, Inc.
Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases.
Immune modulation refers to the ability to upregulate (make more active) or downregulate (make less active) one's immune system.
The Company's corporate website is www.therapeuticsolutionsint.com.
[1] Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote
brain metastasis of breast cancer. Cancer Res. 2016 Sep 1; 76(17): 49704980. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010459/
[2] Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer.Int J Mol
Sci. 2018 Jan 18;19(1). http://www.mdpi.com/1422-0067/19/1/287/pdf
[3] Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78. https://www.ncbi.nlm.nih.gov/pubmed/8958163
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