RE:RE:RE:RE:RE:RE:RE:Time to Market for H2S PipelineYes, completely agree. This was briefly discussed at the AGM as well by Stauffer although at that time awaiting biomarker confirmation.
150 mg x 90 days will not work due to p450 inhibition. Loading could work although challenging for OTC marketing.
150 mg x 14 days works despite p450 inhibition, both safe and effective, hence new strategy.
The answer for chronic use could be as simple as 75 mg x 14 days (25 mg tabs every 8 hours) and then 25 mg daily x 90 days, as you say. Trial should allow for dose reduction on upon LTE prior to discontinuation.
Rawrasaurus wrote:
Mstrmind, I'll look it up but there is parti cyp 450 inhibition. I mentioned it in ceo but I believe it is the c9 pathway (don't quote me til I find the study). It almost certainly is building up due to his inhibition, but can also almost certainly be corrected by dropping the dose and requiring a longer ramp up time before we see clinical significance. From a clinical use, I could see this requiring a loading dose for a few days to a week before the dose gets dropped back to a low once daily dose to maintain serum levels.