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Antibe Therapeutics Inc(Pre-Merger) T.ATE


Primary Symbol: ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Comment by MrMugsyon Jul 27, 2022 2:58pm
177 Views
Post# 34854603

RE:New indications IP

RE:New indications IPCorrect.

Looks like it is also know as ATB-344 or an H2S releasing Indomethacin product.
ATB-344 was initially intended for gout and the market size was about $500M (2013).

For the past 2 years we've been waiting for word of a respiratory/COVID drug - guessing 344 is the winner over Regeneron and ATB-429 (if I recall from the patent).

Also - don't take my word for it as I don't know my chemistry - but - it does look like new H2S chemistry. 

I see an N-thiocarboxy design with minimal acute in vitro toxicity observed in multiple cell lines while longer-term toxicity in cancer cells (if related).  Tuning the H2S release rate might be easier with this design. 

Will see ... if they ever update us.

Then again - I think they owe us a lot of other things before we get any information on this one.  All in my opinion.
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