Resverlogix Corp T.RVX

RE:RE:RE:RE:RVX Communications

[toinv261]

Hi GV. BBQ was a treat. Only drank 1 bottle of wine.

I've put PCSK9 to bed in my head and in my posts and for me they have no relevance at all to rvx-208.

However, my point was the communications they achieved.
Depending on which of the 2 trials you pick, so with evolocumab they stated absolute risk control = 2.18% (at 12 to 18 months), absolute risk test = 0.95%, absolute risk reduction = 1.23% points and they state the RRR is 47% (their calculation) with a 95% confidence interval  from 28% to 78%.

Keep in mind these were post hoc findings (just like SUSTAIN/ASSURE) as San Fran pointed out!

So for these results they received the following quotes;

1. "The data are very impressive," meeting co-chair Jeffery T. Kuvin, MD, a general cardiologist at Tufts Medical Center in Boston, agreed in an interview.
2. "What we see here this weekend puts these drugs on a solid footing for early approval," Steven Nissen, MD, told MedPage today. "As tough a guy as I am, I wouldn't wait...This is probably the most important class of drugs we've seen in a decade."
3. The FDA would be taking little risk with early approval based on this promising but preliminary data because they at best rule out harm, said Nissen, chair of cardiovascular medicine at the Cleveland Clinic and past president of ACC.

These quotes were followed by 1.5 pages of risks.

My comment - "Where is the justice?"

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So here is rvx-208, an epigenetic BET inhibitor aimed at an entirely different patient class than PCSK9.

Sub group diabetes mellitus with CVD - a large and growing segment
Combined analysis of ASSURE/SUSTAIN with 210 days of measurement.

• absolute MACE risk control group(Crestor only) = 20.8%
• absolute MACE risk test group (rvx-208 + Crestor) = 5.1%
• absolute MACE risk reduction = 15.7%
• RRR MACE = 77% with p=0.01

rvx-208 has passed it's safety tests!

So where is RVXs prestigious equivalent to Dr Nissen?

Brand reputation matters!

Anyway, this is my last rant on this.
Cheers
Toinv   :)