RE:RE:Another updateThe CT scan reports I have are from UHN, that is Toronto General , etc. Images are open to interpretation. They talk about node that have increased in size and a few have decreased. I wrote before about the cluster of tumors on her upper right flank, that I thought had decreased. Nothing in the report about it so I measured it myself from the Images and it had shrunk by about 30%. As for the rest it is difficult for me to interpret or verify. I sent a code to the doctors at Karmanos so they can look at the images. I usually do this when scans are done in Toronto. But they did not respond to me. I will send you the code so you can have a look if you want.
qwerty22 wrote: Terrible news Juniper, be strong.
On the progression/ regression at the same time it could be what you described earlier. Baseline readings taken and then treatment delayed for two weeks could have allowed some growth and then the drug works when it's finally taken but it didn't necessarily work on those areas that appeared to progress. Especially if her cancer was progressing rapidly. Generally in these sorts of trials it seems regression happens over multiple cycles so if she could have stayed on treatment longer the regression/progression pattern may have more clearly tilted in one way or the other. I'm guessing what you and your wife are being shown by the doctor is not necessarily just the RECIST tumour outcomes but her total tumour burden? This feels a bit ghoulish to ask but what exactly do you mean by regression and progression? Did new tumours appear? Did certain tumours regress quite strongly? I guess it could be that certain tumours are more accessible to the drug and these are the first to shrink.
Did the doctor say she would have to come off the trial because of the progression or was it just her general health deterioration? It seems particularly sad that she might have found something that might have worked but her frailty got the better of her.
juniper88 wrote: My wife has been move to to Princess Margaret palliative care so that she may be comfortable in whatever time she has left. I have know many of you for many years and I am appreciative of all the good thoughts and prayers. It is a very difficult time for our family, but still I feel the pull to let you all know what I have seen from the phase 1 trial my wife was on. I am writing this post from my cell phone, so everything appears in one paragraph. First, I will disclose that I sold about 10k TH shares because i need the money to pay for the funeral, burial, etc. The second disclosure is that my wife was one the TH1902 trial. We got CT scan reports back earlier this week that showed both regression and progression of tumors. I know for sure that TH1901 works. We can see that from the tumors that regressed and the substantial lowering in my wife's tumor marker. These trials are about research, getting more information. Efficacy would be great but it is complicated. On July 1st I noticed that my wife's eye became yellow again. A few days later she had deteriorated and I toke her to the ER, where they rushed her inside. They did the CT scans and found abscesses in the liver and that the bile duct stent had become blocked. They told me that she had a severe bacterial infection likely originating from the stent, but it also could just be the cancer. We were offered a procedure to replace the stent but we declined, as it would ultimately not change the outcome. The question about the trial I have is why did only some tumors regress? Was it because those tumors did not have SORT1? Or was docetaxel not effective against those? My wife got the 300mg/m2 dosage. She lost almost now hair which tells us that there was very little free docetaxel in her blood. That would also tell us that the tumor regression came because TH1902 rather than free docetaxel. Ovarian cancer is very heterogeneous. So it is very possible that the tumors that progressed were a cancer line resistant in some other way. A more powerful bomb would help. On the other hand if those tumors didn't over express SORT1 then the TH1901 simply wouldn't work against those tumors. Also about the trial, the weekly blood work is onerous on late stage cancer patients. It might even keep some patients out of the trial. But from what I know, recruitment is happening fast.