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Claritas Pharmaceuticals Inc V.CLAS.H

Alternate Symbol(s):  CLAZF

Claritas Pharmaceuticals, Inc., formerly Kalytera Therapeutics Inc, is a biotechnology company that is focused on developing R-107 for the treatment of vaccine-resistant coronavirus disease (COVID) strains. The Company’s products in development include R-107 for coronavirus disease and Viral Infections, R-107 and Vaccines, and CLA-1816 for treatment of pain. R-107 is designed to defeat COVID viruses on contact. R-107 targets the Achilles heel of COVID, the spike protein on the surface of the virus. R-107 releases nitric oxide, which attaches to a specific amino acid on the spike protein, thereby disabling the spike protein. The CLA-1816 provides effective pain reduction, without the risks of addiction or respiratory suppression that exist with opioid analgesics. CLA-1816 strongly binds with and activates the alpha3 glycine pain receptor in the spine. The Company has leased a laboratory, office, and archival space in Beverly, Massachusetts.


TSXV:CLAS.H - Post by User

Post by Red~Oneon Apr 24, 2022 7:19pm
138 Views
Post# 34627706

nitric oxide

nitric oxide

Boosting nitric oxide, the antidote to getting older

BY DR. GIFFORD-JONES & DIANA GIFFORD-JONES ON APRIL 22, 2022.

The French existentialist, Gabriel Marcel, asserted “Life is not a problem to be solved but a mystery to be experienced.” Nevertheless, scientists remain intent on figuring it out.

The cells in our bodies are susceptible to damage. A sunburn is a visible example. Ultraviolet rays scorch skin cells, causing rapid death. Damage occurs at a slower pace from poor diet, excessive alcohol, smoking, and all kinds of physical and mental stress. Over time, the biological process of replacing damaged cells through replication involves compounding errors, and cells die completely. When too many cells die, biological systems start to falter. This, in short, is aging.

Researchers are exploring experimental drugs, essential trace minerals, and even calorie restriction as avenues to longer lives.

What is the best course in the meantime? Practice preventive medicine from an early age and stick with it. But what if you are already well along in life’s course? Aging is not a prospect; it is a daily reality.

Are you feeling tired, falling asleep in the afternoon, losing your keys or interest in sex? Are you concerned about cardiovascular disease, hypertension, osteoporosis, high cholesterol, diabetes and its complications? Do you want to limit the pain and swelling of arthritis, calm the inflammation of asthma and assist the immune system in fighting infection?

The older one gets, hopefully the wiser too. That means a look at history. In 1998, Robert F. Furchgott, Louis J. Ignarro and Ferid Murad shared the Nobel Prize in Physiology and Medicine for their discoveries on the role of nitric oxide in the cardiovascular system.

Researchers had long known that nitroglycerine eased coronary pain by increasing blood supply to the heart’s muscle. But it remained a mystery why arteries expanded until these Nobel laureates explained how nitric oxide sends messages to every cell in the body in nanoseconds.

Nitric oxide first attained star status in the treatment of male impotence. Erectile dysfunction is cured by drugs that produce nitric oxide, sending increased amounts of blood to the penis.

Early in life we produce large amounts of nitric oxide in the endothelial lining (the innermost lining) of blood vessels. This keeps arteries expanded. But after age 40, production of nitric oxide decreases, arteries constrict causing hypertension, and constant pressure injures the inner wall of coronary arteries. This damage results in a chemical and inflammatory reaction that kills one North American every 37 seconds.

As many as 27 million North Americans also suffer from arthritis, a debilitating condition. When nitric oxide increases circulation, nerve and joint inflammation decreases, which can result in dramatic relief from osteoarthritis.

Another 25 million North Americans suffer from Type 2 diabetes due to obesity and 57 million others have borderline diabetes. High blood sugar gradually destroys the circulatory system resulting in heart attack, stroke, kidney failure, blindness, amputation of legs, and it doubles the risk of Alzheimer’s Disease.

Decreased amounts of nitric oxide may play a major role in the development of Type 2 diabetes. Low levels result in insulin resistance making it difficult for insulin to enter cells to maintain a normal blood sugar level. Italian researchers found that diabetes patients who also had kidney disease had nitric oxide levels 37 per cent lower than healthy people.

Nitric oxide levels are significantly lower in patients suffering from depression too.

To get more nitric oxide, add leafy greens and beets to the diet. Nitric oxide supplements work quickly when the need for a boost is more urgent.

 


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