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IBEX Technologies Inc., through its wholly owned subsidiary, IBEX Pharmaceuticals Inc., manufactures and markets enzymes for biomedical use. IBEX Pharmaceutical Inc.’s primary business is the manufacture and selling of high purity enzymes for in-vitro diagnostics and research. The Company also makes and sell osteoarthritis kits (ELISA’s) for pre-clinical research. The Company has developed a... see more

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IBEX Technologies Inc > Diamine oxidase supplements improve symptoms in HIT patients

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Post by guarantor1 on Sep 09, 2022 6:22am

Diamine oxidase supplements improve symptoms in HIT patients

2019,
From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859183/
Diamine oxidase supplementation improves symptoms in patients with histamine intolerance

Wolfgang J. Schnedl, corresponding author

1 Michael Schenk,2 Sonja Lackner,3 Dietmar Enko,4 Harald Mangge,5 and Florian Forster6

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Abstract

Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine. For this open-label interventional pilot study, we identified 28 patients with HIT. For 4 weeks, they were instructed to take DAO capsules before meals. Then, throughout a follow-up period, they were instructed not to take the DAO. We used a questionnaire that included 22 symptoms, which were divided into 4 categories, as well as a symptom severity score. All symptoms improved significantly during the oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms. We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements.

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