RE:RE:RE:Systemic injection vs direct intra-tumorWow thats fantastic information your sharing with the board PatK. Nice to contribute to constructive discussion, eh?
I trust you have a source for this information and the timeline you report is rock solid. For you to comment on projected timelines you must have had them written in blood and notarized.
Lilge commented on intra-tumor injection when asked about treating larger extensive tumors. His comment was that TLT could treat the tumor via bladder instillation of TLD-1433 in possible combination with intratumor injection and possible surgical resection for extensive cases.
There really should be no reason that TLD-1433 could not be used IV. If Rutherin has an affinity for transferrin binding sites that are plentiful on cancerous tumors and Rutherin demonstrates non-toxicity to normal cells then we should be in the clear. The issue wil be around whether or not we can get the light to some of these tumors.
Toxicity will need to demonstrate that when delivered IV, that there is a reasonable time for the drug to clear the body and that it is excreted or metabolized and that there is no toxicity to other cells/organs.
THis will come with time, I am focused on he current proposed trial in bladder cancer. This is the shortest pathway to approval of this drug/technology. Once the SP reponds to positive results in human trials there will be plenty of cash/offers/partnerships to take this to the next level and another trading platform.
Runner