Theralase Technologies Inc. V.TLT

Good News

[Johnandrose22]

The company has launched a sixth clinical site in San Antonio Texas. Patient #16 has been treated.

[Longholder99]

These American mega sites could treat all 9 required in about 2 weeks. More notoriety in a big market as US results surface. All good stuff.

[99942Apophis]

Longholder99 wrote These American mega sites could treat all 9 required in about 2 weeks. More notoriety in a big market as US results surface. All good stuff. You're not alone in that thought Longholder99, yes and would be comforting to speculate that with 11 clinical study sites and as more vaccinations done on both sides of the border the wheel will be picking up speed. 

[enriquesuave]

Looks like they are getting ready to treat those 9 soon " early 2021". IMo   "It is truly uplifting to be working on the details of getting patients enrolled and treated at these sites. Theralase is another step closer in achieving its next milestone of enrolling and treating 9 additional patients in early 2021 to meet the target of 25 patients for potential Breakthrough

[Oden6570]

Agreed, the light in the tunnel looks a little brighter.

[Johnandrose22]

If my recollection is accurate, with each announcement of a new clinical site launch the company continues to indicate their goal of applying for Breakthrough Designation. This seems to indicate to me that the company remains confident that, not only will they reach 25 treated patients but that their clinical data to date continues to support that application. I anticipate the next set of data

[fredgoodwinson]

Yes the further positive takeaways are that 4 patients should now have received an optimal first dose enabling a start to the drawing of meaningful conclusions in the not too distant future and from what the CEO says that something must and will change very soon on treatments from what still has the appearance of being 1 a month at UHN.   

[Longholder99]

When the American public finds out that a treatment like this exists. They won't take no for an answer. Its just a matter of time and a few well placed NRs before Right to Try takes this through the goal posts. What would you want for your loved one? Endless side effects and marginal efficacy? With an eventual bag hanging down your leg? Or one (or two) and done very effective outpatient

[jicoop]

At least they got into the south west now, and close to one of the best treatment centers in University of Texas MD Anderson Cancer center, so this is promising. Urology San Antonio is the largest urology practice in South Texas with multiple locations offering care for men and women experiencing complications of the urinary system. Their subspecialists develop incredible expertise in different

[CancerSlayer]

  Agree Fred....I am hoping the FDA ultimately dismisses the previous "unrepresentative" data.  Those patients who were removed (based on the now discarded protocol) negatively biased the data.  Based on the updated protocol, such data would be considered invalid & should also be discarded imo = not included in the final analysis.   Based on other granted BTDs

[fredgoodwinson]

Absolutely CancerSlayer. For those of us with confidence in this tech recruitment is the key atm and what wouldn’t it do to boost numbers if they had good 90-day data that they could publish on 13 & 14 right now?

[CancerSlayer]

I agree...speedy recruitment is key, especially when on a limited budget.  To publish or not to publish?  It's always a delicate balance between presenting more statistically significant data & presenting more impactful data.  My guess is good 90-day data in at least 6+ US-treated patients will hopefully get us some great news.  JMO.

[fredgoodwinson]

They`ve published Clinical Trial data really very early at times (38 days` after treating P.6 in Phase IB from memory) so it is their call. Just a sense that recruitment is floundering a bit atm and that it`s not just Covid.

[CancerSlayer]

For a novel Ph 1, I'm not too surprised they published early.  A Ph 2 primary endpoint of CR (at any time) simply requires more meaningful data/more time imo.  As for patient accrual, we are still in the relatively early stages for the US trials...I expect we'll be well ahead of Canada in very short order. Though 16 treated patients to date may seem low, we could very well have

[tamarindo1]

I agree, I'm an 85 year old 3 pee a night gaffer.

[99942Apophis]

tamarindo1 wrote I agree, I'm an 85 year old 3 pee a night gaffer. I attended a nutrition class a couple of years ago that problem came up, the nutritionist suggested eat your evening meal no later than 5pm and no snacks or liquids after your meal, she said this would reduce your washroom trips and might even eliminate them. 

[tamarindo1]

Thank you:  My evening glass of wine forbidden?  No thank you, I'll carry on peeing, at this stage in life small pleasures often overide those things that may improve quality or even life extension. :-) 

[99942Apophis]

I think that nutritionist might give you a nod of approval tamarindo1

[tdon1229]

  Next time you visit your doctor/urologist, consider inquiring re using a catheter ... do a self-cath as the last thing each night before bed to completely drain your tank ... even a little bit left from a normal void can result in a premature urge and an extra visit ... my kidneys do their best work while I'm sleeping, but pee o'clock usually only comes once each night after about

[menoalittle]

hey... sounds a bit like my program... lol. getting old is hard... but far better than the alternative!

[fredgoodwinson]

Thanks CancerSlayer. Information from Phase IB was released inconsistently. Good news came quickly or relatively so but the reason for the long period of silence in the middle - when they hit issues - only became clear in retrospect. Much the same could be said of the period prior to the revelation of the dosing debacle at the start of Phase II. Both intervals ended with the requirement for a

[CancerSlayer]

  Yep Fred....it can be anxious times during any "perceived" delay.  Fortunately, any perceived delays moving forward should be scientifically measured ones, & not ones due to controllable oversight.   And not only is there Huuuuge incentive for all parties to do their best, our ACT sets a satisfyingly  low bar for patient compliance.  Name that efficacy

[99942Apophis]

This isn't meant for long shareholders but for some of the newer ones that once a patient is enrolled there is a 28 days waiting period prior to treatment. This would explain current low numbers state side alone with rising numbers in Covid-19 infections in both countries,  in my opinion.

[enriquesuave]

Right on.  I think we will get our 9 more patients by mid May.  Just IMO  

[Bunge]

I feel like it's a sports league that announces the schedule and then keeps announcing that games have been played without ever announcing the SCORES.