This recent paper (November 15) from researchers in the People's Republic of China (Shanghai Jiao Tong University) deals with the use of
X-ray PDT against deep seated tumours. It is clear from the illustration that these researchers regard the clinically approved use of low dose X-ray PDT with PSs such as
TLD1433, as the future trend. The Google Search teaser makes it clear that
TLD-1433 is discussed:
"This short review surveys two recent clin. examples of metal complexes, namely TOOKAD-Sol. and TLD-1433, which have ideal photophys. properties to act as ..." If you want to read the full article you can purchase it for 48 hours for $40.
Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses Liangrui He, Xujiang Yu*, and Wanwan Li*
The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires innovative solutions for its congenitally deficient shadow penetration of the visible-light excitation. X-ray-induced photodynamic therapy (X-PDT) has been proven to be a successful technique in reforming the conventional PDT for deep-seated tumors by creatively utilizing penetrating X-rays as external excitation sources and has witnessed rapid developments over the past several years. Beyond the proof-of-concept demonstration, recent advances in X-PDT have exhibited a trend of minimizing X-ray radiation doses to quite low values. As such, scintillating materials used to bridge X-rays and photosensitizers play a significant role, as do diverse well-designed irradiation modes and smart strategies for improving the tumor microenvironment. Here in this review, we provide a comprehensive summary of recent achievements in X-PDT and highlight trending efforts using low doses of X-ray radiation. We first describe the concept of X-PDT and its relationships with radiodynamic therapy and radiotherapy and then dissect the mechanism of X-ray absorption and conversion by scintillating materials, reactive oxygen species evaluation for X-PDT, and radiation side effects and clinical concerns on X-ray radiation. Finally, we discuss a detailed overview of recent progress regarding low-dose X-PDT and present perspectives on possible clinical translation. It is expected that the pursuit of low-dose X-PDT will facilitate significant breakthroughs, both fundamentally and clinically, for effective deep-seated cancer treatment in the near future.