WINNIPEG, Manitoba, Feb. 21, 2017 (GLOBE NEWSWIRE) -- 3D Signatures Inc. (TSXV:DXD) (OTCQB:TDSGF) (FSE:3D0) (the
"Company" or "3DS") is pleased to announce that later today Dr. Sabine Mai, its co-founder and principle inventor, will present the
results of a prospective blood-based prostate cancer pilot study using the Company’s proprietary TeloViewTM software
platform. The results will be presented at the 24th International Molecular Medicine Tri-Conference in San Francisco, CA. Based on
blinded blood samples, TeloViewTM correctly predicted the stability and aggressiveness of disease for each of the
study’s 50 intermediate risk prostate cancer patients.
A prospective prostate cancer patient cohort was assessed to evaluate TeloViewTM’s potential to
blindly stratify 50 intermediate risk prostate cancer patients (Gleason 7, PSA <20) and monitor their disease progression or
stability. Patients were recruited after informed consent, blood was drawn and circulating tumor cells (“CTCs”) were isolated prior
to radical prostatectomy. CTCs were isolated from blood samples from each of the 50 patients.1 Surgery results
correlated with the observed three-dimensional nuclear telomeric profiles from CTCs and indicated that the TeloView platform
correctly identified each patient with stable vs. progressive disease (p=0.0175).
“These results are extremely encouraging,” stated Jason Flowerday, CEO of 3DS. “We believe that the
TeloViewTM software platform is a disruptive technology. It is based on a universal structural biomarker, 3D telomere
organization, that has generated impressive results across a number of diseases, with prostate cancer being one of our highest
priorities.”
In previous clinical research, TeloViewTM has also demonstrated the ability to identify and profile
multiple CTC clones within a single patient (heterogeneity)1,2 as well as the ability to monitor and quantify
changes to 3D telomere profiles as a result of treatment (before and after).3 Based on clinical data produced by
Dr. Mai and her colleagues, 3DS believes that TeloViewTM is a promising candidate for development as an accurate,
blood-based risk-assessment and monitoring platform for prostate cancer.
As announced on October 19, 2016, TeleViewTM will be included in a multicenter Canada-wide prostate
cancer clinical trial, known as PRECISE, to identify and monitor prostate cancer patients suitable for active surveillance.
About 3DS
3DS (TSXV:DXD) (OTCQB:TDSGF) (FSE:3D0) is a personalized medicine company with a proprietary software platform
based on the three-dimensional analysis of chromosomal signatures. The technology is well developed and supported by 22 clinical
studies on over 2,000 patients on 13 different cancers and Alzheimer’s disease. Depending on the desired application, this platform
technology can measure the stage of disease, rate of progression of disease, drug efficacy, and drug toxicity. The technology is
designed to predict the course of disease and to personalize treatment for the individual patient. For more information, visit the
Company’s new website at http://www.3dsignatures.com.
Forward-Looking Information
This news release includes forward-looking statements that are subject to risks and uncertainties.
Forward-looking statements involve known and unknown risks, uncertainties, and other factors that could cause the actual results of
the Company to be materially different from the historical results or from any future results expressed or implied by such
forward-looking statements. All statements within, other than statements of historical fact, are to be considered forward looking.
Although 3DS believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such
statements are not guarantees of future performance and actual results or developments may differ materially from those in
forward-looking statements. Risk factors that could cause actual results or outcomes to differ materially from the results
expressed or implied by forward-looking information include, among other things: market demand; technological changes that
could impact the Company’s existing products or the Company’s ability to develop and commercialize future products; competition;
existing governmental legislation and regulations and changes in, or the failure to comply with, governmental legislation and
regulations; the ability to manage operating expenses, which may adversely affect the Company’s financial condition; the
Company’s ability to successfully maintain and enforce its intellectual property rights and defend third-party claims of
infringement of their intellectual property rights; adverse results or unexpected delays in clinical trials; changes in
laws, general economic and business conditions; and changes in the regulatory regime. There can be no assurances that such
statements will prove accurate and, therefore, readers are advised to rely on their own evaluation of such uncertainties. We do not
assume any obligation to update any forward-looking statements.
Neither the TSX Venture Exchange nor its Regulation Service Provider (as that term is defined in the
policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
1 Adebayo Awe J, Saranchuk J, Drachenberg D, Mai S. Filtration-based enrichment of circulating tumor cells from
all prostate cancer risk groups. Urol Oncol. 2017 Feb 12. pii: S1078-1439 (16) 30415.
2 Awe JA, Xu MC, Wechsler J, Benali-Furet N, Cayre YE, Saranchuk J, Drachenberg D, Mai S. 3D telomeric analysis
of isolated circulating tumor cells (CTCs) defines CTC subpopulations. Translational Oncology. 2013 2013 Feb; 6(1):51-65.
3 Wark L, Thomas Klonisch T, Quon H, Mai S. Three dimensional telomere signature dynamics in circulating tumor
cells of early follow-up high-risk prostate cancer patients undergoing androgen-deprivation and radiation therapy. Urol Oncol. 2016
Dec 9. pii: S1078-1439 (16) 30332-5.
For further information, please contact: Stephen Kilmer Investor Relations 647-872-4849 stephen.kilmer@3dsignatures.com OR Hugh Rogers VP Corporate Finance 604-250-6162 investors@3dsignatures.com